Studien und Publikationen

Die Wirksamkeit des PentraSorb® CRP Adsorbers ist durch Studien und Register belegt. Hier finden Sie eine Übersicht über Forschungsergebnisse und Publikationen.

Allgemeine Informationen zu CRP | Kardiovaskuläre Themen | COVID-19 | Neurologische Themen | Spezielles zu CRP

Allgemeine Informationen zu CRP und CRP-Apherese

Biomedicines 2023, 11(8), 2279. doi: 10.3390/biomedicines.11082279. Being Eaten Alive: How Energy-Deprived Cells Are Disposed of, Mediated by C-Reactive Protein — Including a Treatment Option Sheriff A, Kunze R, Brunner P, Vogt B.
Frontiers of Immunology 2023 Jul 26:1237729. doi: 10.3389/fimmu.2023.1237729. C-reactive protein: a target for therapy to reduce inflammation Rizo-Téllez SA, Sekheri M, Filep JG.
Ärzteblatt M-V. 4/2022. C-reaktives Protein – Entzündungsmarker, Nekrosetrigger und therapeutisches Target. Kunze R, Esposito F.
Journal of Clinical Medicine 2022; 11,1771. doi: 10.3390/jcm11071771 Targeting C-Reactive Protein by Selective Apheresis in Humans: Pros and Cons. Torzewski J, Brunner P, Ries W, Garlichs C D, Kayser S, Heigl F, Sheriff A.
Medizinische Klinik – Intensivmedizin und Notfallmedizin. 2022 Mar 28. doi: 10.1007/s00063-022-00911-x. CRP-Apherese bei akutem Myokardinfarkt bzw. COVID-19. Buerke M, Sheriff A, Garlichs C.D.
Frontiers of Immunology 2021 Feb 12:630430. doi: 10.3389/fimmu.2021.630430. C-reactive Protein Triggers Cell Death in Ischemic Cells Sheriff A, Kayer S, Brunner P, Vogt B.
Therapeutic Apheresis and Dialysis 2019 Dec;23(6):494-496. doi: 10.1111/1744-9987.12802. C-Reactive Protein: From Biomarker to Trigger of Cell Death? Kunze, R.
Therapeutic Apheresis and Dialysis 2019 Oct;23(5):474-481. doi: 10.1111/1744-9987.12796. Epub 2019 Mar 21. PentraSorb C-Reactive Protein: Characterization of the Selective C-Reactive Protein Adsorber Resin Mattecka S, Brunner P, Hähnel B, Kunze R, Vogt B, Sheriff A.

Kardiovaskuläre Themen

Journal of Clinical Medicine 2022; 11(13), 3610. doi: 10.3390/jcm11133610 Special Issue “C-Reactive Protein and Cardiovascular Disease: Clinical Aspects”. Sheriff A.
Front Cardiovasc Med 2024; doi: 10.3389/fcvm.2024.1401566 Case Report: C-reactive protein apheresis in non-ST-elevation ACS-case series from the C-reactive protein apheresis in Acute Myocardial Infarction Registry Torzewski J, Mattecka S, Esposito F, Heigl F, Fiedler J, Sheriff A.
Current Pharmaceutical Design 2023; 8, doi: 10.2174/13816128 ^^29666230310090601 C-reactive Protein Apheresis in Acute Myocardial Infarction Study Milosevic M, Balint B, Ilic I, Dukuljev N, Otasevic P.
Frontiers in Drug Discovery 2023; doi: 10.3389/fddsv.2023.1286710 Case report: C-reactive protein apheresis in cardiogenic shock: case series from the C-reactive protein apheresis in acute myocardial infarction-registry Torzewski J, Mattecka S, Ries W, Garlichs CD, Heigl F, Fiedler J, Sheriff A.
Cellular and Molecular Biology 2023; doi: 10.14715/cmb/2023.69.12.9 Relationship between dynamic electrocardiogram and CRP, IL-6, ET-1 expression in myocardial ischemia patients with coronary heart disease You, L.
Nephro News. Ausgabe 2/2021; Jahrgang 23: 23-26 Medicom | CRP-Apherese beim Myokardinfarkt: Eine neue Domäne der Nephrologie? Gauckler P, Mayer G.
Front Cardiovasc Med. 2021 Mar 8:591714. doi: 10.3389/fcvm.2021.591714. C-Reactive Protein Apheresis as Anti-inflammatory Therapy in Acute Myocardial Infarction: Results of the CAMI-1 Study Ries W, Torzweski J, Heigl F, Pfluecke C, Kelle S, Darius H, Ince H, Mitzner S, Nordbeck P, Butter C, Skarabis H, Sheriff A, Garlichs CD, on behalf of the CAMI-1 Investigators.
International Journal of Cardiology 2020 Dec 9;328:191-196. doi: 10.1016/j.ijcard.2020.12.006. High sensitivity C-reactive protein is associated with worse infarct healing after revascularized ST-elevation myocardial infarction. Tiller C, Reindl M, Holzknecht M, Lechner I, Simma F, Schwaiger J, Mayr A, Klug G, Bauer A, Reinstadler SJ, Metzler B.
Blood Purification 2020 Feb 28:1-5. doi: 10.1159/000506176. A Promising Innovative Treatment for ST-Elevation Myocardial Infarction: The Use of C-Reactive Protein Selective Apheresis: Case Report Boljevic D, Nikolic A, Rusovic S, Lakcevic J, Bojic M, Balint B.
Therapeutic Apheresis and Dialysis 2019 Dec;23(6):570-574. doi: 10.1111/1744-9987.12804. Epub 2019 Apr 29. Selective C-Reactive Protein-Apheresis in Patients. Ries W, Heigl F, Garlichs C, Sheriff A, Torzewski J.
Case Reports in Cardiology 2018 Nov 6;2018:4767105. doi: 10.1155/2018/4767105. eCollection 2018. “First in Man”: Case Report of Selective C-Reactive Protein Apheresis in a Patient with Acute ST Segment Elevation Myocardial Infarction. Ries W, Sheriff A, Heigl F, Zimmermann O, Garlichs CD, Torzewski J.
Clinical Cardiology 2018 Jun 27;41(9):1201-1206. doi: 10.1002/clc.23017. C-reactive protein during and after myocardial infarction in relation to cardiac injury and left ventricular function at follow-up. Vanhaverbeke M, Veltman D., Pattyn N, De Crem N, Gillijns H, Cornelissen V, Janssens S, Sinnaeve PR.
European Heart Journal 2017 Oct 1;6(7):640–649. doi: 10.1177/2048872616661691. Relation of inflammatory markers with myocardial and microvascular injury in patients with reperfused ST-elevation myocardial infarction. Reindl M, Reinstadler SJ, Feistritzer H, Klug G, Tiller C, Mair J, Mayr A, Jaschke W, Metzler B.
Archives of Medical Science 2017 Aug;13(5):1086-1093. doi: 10.5114/aoms.2017.69327. Epub 2017 Aug 3. C-reactive protein levels predict systolic heart failure and outcome in patients with first ST-elevation myocardial infarction treated with coronary angioplasty. Stumpf C, Sheriff A, Zimmermann S, Schaefauer L, Schlundt C, Raaz D, Garlichs CD, Achenbach S.
BMC Cardiovascular Disorders 2016 Nov 28;16(239). doi: 10.1186/s12872-016-0415-z. Multimarker approach for the prediction of microvascular obstruction after acute ST-segment elevation myocardial infarction: a prospective, observational study. Feistritzer H, Reinstadler SJ, Klug G, Reindl M, Wöhrer S, Brenner C, Mayr A, Mair J, Metzler B.
Journal of Clinical Apheresis 2015 Feb;30(1):15-21. doi: 10.1002/jca.21344. Epub 2014 Jul 5. Selective apheresis of C-reactive protein: a new therapeutic option in myocardial infarction? Sheriff A, Schindler R, Vogt B, Abdel-Aty H, Unger JK, Bock C, Gebauer F, Slagman A, Jerichow T, Mans D, Yapici G, Janelt G, Schröder M, Kunze R, Möckel M.
New England Journal of Medicine 2006 Aug 3;355(5):513-5. Limiting myocardial damage during acute myocardial infarction by inhibiting C-reactive protein. Kitsis RN, Jialal I.
Nature. 2006 Apr 27;440(7088):1217-21. Targeting C-reactive protein for the treatment of cardiovascular disease. Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP.
Journal of Experimental Medicine 1999 Dec 20;190(12):1733-40. C-reactive protein and complement are important mediators of tissue damage in acute myocardial infarction. Griselli M, Herbert J, Hutchinson WL, Taylor KM, Sohail M, Krausz T, Pepys MB.

COVID-19

Journal of Clinical Medicine 2022; 11,1956. doi: 10.3390/jcm11071956 Seven COVID-19 Patients Treated with C-Reactive Protein (CRP) Apheresis. Esposito F, Matthes H, Schad F.
Am Journal of Case Reports 2021 Dec 30. In Press: DOI: 10.12659/AJCR.935263 A Report on the First 7 Sequential Patients Treated Within the C-Reactive Protein Apheresis in COVID (CACOV) Registry. Schumann C, Heigl F, Rohrbach I, Sheriff A, Wagner L, Wagner F, Torzewski J.
Frontiers in Immunology 12:708101. doi: 10.3389/fimmu.2021.708101 Case Report: C- Reactive Protein Apheresis in a Patient With COVID-19 and Fulminant CRP Increase. Ringel J, Ramlow A, Bock C and Sheriff A.
American Journal of Case Reports 2021 Jul 27: 22: e932964. doi: 10.12659/AJCR.932964 Successful Treatment of a 39-Year-Old COVID-19 Patient with Respiratory Failure by Selective C-Reactive Protein Apheresis. Torzewski J, Zimmermann O, Kayser S, Heigl F, Wagner F, Sheriff A, Schumann C.
European Heart Journal 2021 Mar 29: ehab169, doi: 10.1093/eurheartj/ehab169 C-reactive protein predicts outcome in COVID-19: is it also a therapeutic target?. Pepys MB.
European Heart Journal 2021 Jan 21: ehaa1103. doi: 10.1093/eurheartj/ehaa1103 C-reactive protein and clinical outcomes in patients with COVID-19. Smilowitz NR, Kunichoff D, Garshick M, Shah B, Pillinger M, Hochman JS, Berger JS.
Cell Reports Medicine 2020 Nov 17: 1;8. doi: 10.1016/j.xcrm.2020.100144 Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients. Mueller AA, Tamura T, Crowley CP, DeGrado JR, Haider H, Jezmir JL, Keras G, Penn EH, Massaro AF, Kim EY.
MedPage Today 2020 Jul 27 Apheresis gets Tryout in COVID-19 Kate Kneisel
American Journal of Case Reports 2020 Jul 14:21:e925020. doi: 10.12659/AJCR.925020 First-in-Man: Case Report of Selective C-Reactive Protein Apheresis in a Patient with SARS-CoV-2 Infection. Torzewski J, Heigl F, Zimmermann O, Wagner F, Schumann C, Hettich R, Bock C, Kayser S, Sheriff A.
Therapeutic Apheresis and Dialysis 2020 Jun 05. doi: 10.1111/1744-9987.13532 Selective C-reactive protein apheresis for Covid-19 patients suffering from organ damage. Kayser S, Kunze R, Sheriff A.

Neurologische Themen

Journal of Clinical Medicine 2020 Sep; 9(9):2974. Selective Apheresis of C-Reactive Protein for Treatment of Indications with Elevated CRP Concentrations. Kayser S, Brunner P, Althaus K, Dorst J, Sheriff A.
Journal of Cerebral Blood Flow & Metabolism 2004 Nov; 24(11):1214-8. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. Gill R, Kemp JA, Sabin C, Pepys MB.

Spezielles zu CRP

Frontiers of Immunology 2018 Jun 12;9:1351. doi: 10.3389/fimmu.2018.01351. Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes. McFadyen JD, Kiefer J, Braig D, Loseff-Silver J, Potempa LA, Eisenhardt SU, Peter K.
Circulation 2014 Apr 28;130:35–50. doi: 10.1161/CIRCULATIONAHA.113.007124. Dissociation of Pentameric to Monomeric C-Reactive Protein Localizes and Aggravates Inflammation. Thiele JR, Habersberger J, Braig D, Schmidt Y, Goerendt K, Maurer V, Bannasch H, Scheichl A, Woollard KJ, Dobschütz E, Kolodgie F, Virmani R, Stark B, Peter K, Eisenhardt SU.
J. Clin. Med. 2022; 11(4), 1058. doi: 10.3390/jcm11041058. C-Reactive Protein (CRP) Blocks the Desensitization of Agonistic Stimulated G Protein Coupled Receptors (GPCRs) in Neonatal Rat Cardiomyocytes. Wallukat G, Mattecka S, Wenzel K, Schrödl W, Vogt B, Brunner P, Sheriff A, Kunze R.
Frontiers of Immunology 2020 Aug 28:11. doi: 10.3389/fimmu.2020.01978 C-reactive Protein causes Blood Pressure Drop in Rabbits and induces Intracellular Calcium Signaling Bock C, Vogt B, Mattecka S, Yapici G, Brunner P, Fimpel S, Unger JK, Sheriff A.