Pioneering technology for inflammation control
Pentracor Healthcare Technology GmbH (PHCT) markets PentraSorb® CRP, the only immunoadsorber that selectively removes C-reactive protein (CRP).
CRP is not a passive biomarker - it is an active trigger of inflammation
CRP is known as an inflammatory marker, but plays an active role in the immune response:
Recognition of danger signals
CRP binds to certain structures (e.g. phosphorylcholine) found on the surface of dead or damaged cells and certain bacteria.
Activation of the complement system
Through this binding, CRP can activate the complement system - a cascade of proteins in the blood that helps to mark pathogens (opsonization) and destroy them.
Opsonization, i.e. marking
CRP acts like a light signal. It marks cells or pathogens for scavenger cells (macrophages, neutrophils) so that they can better recognize and eliminate them.
Laboratory value for inflammation
CRP is an important inflammation marker in the laboratory. If the value in the blood rises sharply, this indicates acute inflammation - for example due to infections or tissue damage.
Function as a mediator
Excessive immune reactions can impair the course of the disease.
“The PentraSorb® CRP-based therapy offers a new option for patients with ischemic or severe inflammatory diseases.”
New therapeutic approach
PentraSorb® CRP can be used to control and specifically modulate inflammatory processes in order to reduce tissue damage and improve healing processes.
Better chances of recovery
How does CRP apheresis work?
CRP apheresis with the PentraSorb® CRP is an extracorporeal blood purification procedure in which the blood is filtered outside the body. The adsorber selectively binds and removes CRP, while all other blood components remain unchanged. The method can slow down an immune reaction, prevent tissue damage and accelerate the recovery process.
For which diseases is the therapy suitable?
An elevated CRP level is associated with a poorer prognosis in many diseases. CRP apheresis is currently being investigated and used for
Acute myocardial infarction
Stroke
COVID-19 Pneumonia
Acute pancreatitis
Cardiogenic shock
Mobus Crohn & ulcerative colitis
This therapy option opens up new treatment options according to the latest scientific findings. To date, the procedure has been clinically tested in over 1000 applications.